Start with what life feels like now
What if pain involves more than the place that hurts?
We help people with pain that limits sitting, walking or sleeping by examining movement and nervous-system factors so that they can work toward the activities pain has interrupted.
How we look at the whole picture
You plan your day around how long you can sit, stand or walk before pain takes over.
You have tried to keep going, but a sore neck, back or joint keeps bringing you back to the same limits.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
In their own words
We understand your experience of Complex Pain & Neurogenic Inflammation
People often describe it in their own words long before anyone gives it a name. If one of these sounds like you, you are in the right place.
“My pain is everywhere and it doesn’t match any injury or diagnosis.”
“Normal sensations feel painful — light touch, sounds, temperature changes.”
“I’ve seen pain specialists, but nothing has made a lasting difference.”
“I was told it’s fibromyalgia, but nobody has explained what’s actually happening.”
Illustrative experiences, in the words people commonly use. The portraits are AI-generated and do not show patients.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
Pain can involve tissue, movement, nerve sensitivity, sleep and stress. The seven-domain approach considers how these factors may be sustaining the problem.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
We review the pattern of pain, the examination and any relevant prior imaging. We agree on a functional goal, such as sitting through a meal or walking farther, before choosing care.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationRecovery Pathway
Complex Pain & Neurogenic Inflammation
Pain that has outlasted its original cause and spread beyond its original site
Conceptual artwork for the care discussion. Individual findings and treatment options require clinical evaluation.
What is happening in your nervous system
Complex pain conditions involve central sensitization — a state in which the spinal cord and brain amplify pain signals, reduce their threshold, and generalize their spread beyond the original site or trigger. Domain 1 (Brain Function & Neural Networks) is involved when descending pain-modulation circuits become dysregulated, reducing the brain’s ability to gate and suppress pain signals. Domain 2 (Autonomic Regulation) matters because the autonomic nervous system modulates inflammation and pain amplification — a dysregulated autonomic state can sustain and intensify the pain picture. Domain 3 (Immune Function & Neuroinflammation) contributes when neuroinflammatory signaling amplifies spinal cord pain processing. Domain 5 (Structure, Stability & Body-to-Brain Signals) is relevant when structural contributors — cervical instability, joint hypermobility, or peripheral nerve sensitization — sustain central sensitization from below.
Domains most involved:
Every plan starts from the same map: the 7 Domains of Recovery.
How it fits your plan
We evaluate all four domains and identify the specific pattern driving sensitization in your case. Neurorehabilitation and pain neuroscience education are the foundation. Autonomic regulation addresses the Domain 2 contribution. Structural assessment evaluates whether peripheral contributors are sustaining central sensitization. Advanced tools are introduced only when the clinical picture supports them and always within the framework of the primary rehabilitation approach. We default to the simplest, lowest-risk intervention that can move a domain forward — and escalate to more advanced or interventional care only when the evidence and the patient’s course support it.
We review your history, explain the findings, agree on next steps and check how you respond.
Potential Therapies
We use established medicine where it works, and emerging medicine where it makes sense.
These are options to discuss after evaluation, not a predetermined treatment plan. Each label refers to the condition or indication described beside that therapy; evidence can differ for another use. An evidence label does not mean FDA approval.
- Pain Neuroscience EducationEvidence: Established
Understanding central sensitization is the foundation for effective rehabilitation.
- NeurorehabilitationEvidence: Established
Restoring normal pain-modulation circuits and descending inhibition in Domain 1.
- Autonomic RegulationEvidence: Established
Addressing Domain 2 autonomic contribution to pain amplification.
- Structural Assessment & InterventionEvidence: Established
Domain 5 evaluation for cervical, hypermobility, and peripheral contributors.
- Stellate Ganglion Block (SGB)Evidence: Established
Established for selected sympathetically mediated pain conditions; considered where sympathetic hyperactivity is a significant contributor to the pain picture.
Where the evidence stands
Evidence varies by therapy and by condition. Each therapy on this page carries its own evidence label for this condition, from established to investigational.
How we grade evidence
Frequently asked questions
What is central sensitization?
Central sensitization is a state in which the spinal cord and brain have amplified their pain-processing circuits — lowering the threshold for pain, broadening the area that feels painful, and sustaining pain long after the original trigger. It explains why complex pain conditions feel disproportionate to any identifiable tissue damage.
Is fibromyalgia a real condition?
Yes. Fibromyalgia reflects central sensitization and dysregulated pain modulation — a real neurological state, not fabricated symptoms. The absence of visible tissue damage on imaging does not mean the pain is not real; it means the pain is being generated at the network level.
How does autonomic dysfunction contribute to complex pain?
The autonomic nervous system modulates inflammation and pain amplification in the spinal cord. Sustained sympathetic overactivity — a dysregulated autonomic state — can intensify and sustain central sensitization. Addressing the autonomic picture is often a key part of complex pain treatment, not a secondary concern.
Does Neuregen replace my pain management specialist?
No. Neuregen focuses on the neurological and autonomic dimensions of complex pain that pain management practices may not fully address. We work alongside, not against, your existing pain care.
Start with a Strategy Consultation
A real clinical conversation, not a sales call. We review your history, answer your questions, and discuss with you whether Neuregen is the right fit.
8090 N. 85th Way, Suite 100, Scottsdale, AZ 85258 · Mon–Thu, 9:00 AM – 5:30 PM