Start with what life feels like now
What if immune symptoms and brain fog belong in one conversation?
We help people with unpredictable reactions, fatigue and brain fog by examining immune symptoms alongside other systems so that they can work toward a day that is easier to plan.
How we look at the whole picture
A meal, a smell or an ordinary outing can leave you feeling unwell, and the pattern is difficult to explain.
You may be tracking triggers while also dealing with poor sleep, fatigue or trouble thinking clearly.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
In their own words
We understand your experience of Immune System & Nervous System
People often describe it in their own words long before anyone gives it a name. If one of these sounds like you, you are in the right place.
“My brain fog, fatigue, and neurological symptoms seem driven by inflammation — not a structural problem.”
“I’ve been told it’s autoimmune, MCAS, mold illness, or post-viral — the diagnosis keeps changing.”
“My symptoms got dramatically worse after an infection or a new environment.”
“Standard immunology doesn’t address the neurological and psychiatric piece of what I’m experiencing.”
Illustrative experiences, in the words people commonly use. The portraits are AI-generated and do not show patients.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
Immune symptoms can coexist with changes in energy, autonomic responses and concentration. We look across the seven domains without assuming that one label explains everything.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
We review the timing of symptoms, suspected triggers, prior diagnoses and current care. Testing is chosen to answer specific questions rather than adding a standard panel for everyone.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationFlagship Condition
Immune System & Nervous System
The dysregulated immune system, tormenting the nervous system.
Clinically: Autoimmune-neurologic, MCAS, mold/Lyme-related, and post-viral immune dysregulation — with the brain and nervous system as the primary target.
Conceptual artwork for the care discussion. Individual findings and treatment options require clinical evaluation.
- Multi-Domain Evaluation
- Cross-Trained, Provider-Led Care
- One Integrated Recovery Plan
- Rehabilitation Throughout
- Clear Evidence, Honest Guidance, Shared Decisions
- Transparent Fees
The immune system and the nervous system
Video in production
What is happening in your nervous system
Immune dysregulation injures the nervous system through several overlapping mechanisms. In classic autoimmune neurologic disease, pathogenic antibodies target neural tissue directly. In MCAS, mold-related illness, and post-viral presentations, dysregulated mast cells and innate immune activation drive neuroinflammation through the blood-brain barrier — activating microglia, impairing cerebral blood flow, and producing the brain fog, fatigue, and cognitive dysfunction that characterize these presentations. Domain 3 (Immune Function & Neuroinflammation) is the primary site. Domain 2 (Autonomic Regulation) is affected because immune-autonomic crosstalk is extensive: inflammation alters heart rate variability and orthostatic tolerance. Domain 1 (Brain Function & Neural Networks) suffers when persistent neuroinflammation reduces network efficiency and connectivity. The Complex Immune & Neuroinflammatory pathway page covers the symptom-pattern entry point for patients exploring this category without a specific diagnosis.
Domains most involved:
Every plan starts from the same map: the 7 Domains of Recovery.
How it fits your plan
We identify the specific immune mechanism first — autoimmune-neurologic, MCAS-driven, mold or Lyme-related, or post-viral. The most established tools are applied first: conventional immune-directed medical management, environmental assessment and exposure remediation where relevant, and autonomic rehabilitation. Therapeutic plasma exchange is an established therapy in classic autoimmune neurologic disease; for mold-related neurologic illness, MCAS, and post-viral presentations it is labeled investigational or emerging and offered with explicit informed consent. EBOO carries investigational evidence as a metabolic and neuroinflammatory adjunct. We default to the simplest, lowest-risk intervention that can move a domain forward — and escalate to more advanced or interventional care only when the evidence and the patient’s course support it.
When sensitivities, fatigue, dizziness and brain fog occur together, we review the history across immune, autonomic and cognitive domains. A therapy is considered for a specific finding or question, not simply because several symptoms occur together.
When rehabilitation alone gets you most of the way but a barrier remains, we can medically escalate inside the same clinical relationship instead of referring you out.
We review your history, explain the findings, agree on next steps and check how you respond.
Potential Therapies
We use established medicine where it works, and emerging medicine where it makes sense.
These are options to discuss after evaluation, not a predetermined treatment plan. Each label refers to the condition or indication described beside that therapy; evidence can differ for another use. An evidence label does not mean FDA approval.
- Functional Neurology AssessmentEvidence: Established
Baseline evaluation of neural network, autonomic, and immune-driven dysfunction.
- Conventional Immune-Directed Medical ManagementEvidence: Established
Most-established first; appropriate supportive care per the clinical picture.
- Environmental & Exposure AssessmentEvidence: Established
Prerequisite in mold/Lyme cases: identify and remediate the driving exposure.
- Autonomic Regulation & RetrainingEvidence: Established
Domain 2 partner to the immune work: HRV biofeedback, breathing and vagal retraining, orthostatic conditioning.
- Stellate Ganglion Block (SGB)Evidence: Preliminary
Where autonomic dysregulation is driving the immune picture; used as one step, not a standalone treatment.
- Therapeutic Plasma Exchange (autoimmune neurologic)Evidence: Established
Established for classic autoimmune neurologic disease per clinical guidelines.
- Therapeutic Plasma Exchange (mold/Lyme)Evidence: Investigational
For mold-related neurologic illness; early-stage evidence, offered with informed consent.
- Therapeutic Plasma Exchange (MCAS)Evidence: Investigational
For MCAS with significant immune dysregulation; investigational for this indication.
- Therapeutic Plasma Exchange (Long COVID)Evidence: Emerging
For post-viral neuroinflammatory presentations; emerging evidence.
- EBOOEvidence: Investigational
Metabolic and neuroinflammatory support; investigational adjunct, not standalone.
Where the evidence stands
Evidence varies by therapy and by condition. Each therapy on this page carries its own evidence label for this condition, from established to investigational.
How we grade evidence
Which of these is you?
For the patient
I have an immune-related neurological condition.
Whether your diagnosis is autoimmune, MCAS, mold illness, or post-viral — if the brain and nervous system are the primary targets, Neuregen’s program is built around that picture. Explore what immune-neurologic care looks like at Neuregen.
Mode of care: Reversal
Explore Advanced TreatmentFor a loved one
My family member has an immune neurological condition.
Immune-driven neurological illness can be hard to explain and harder to treat. We can help you understand what’s happening and what a comprehensive, evidence-labeled program involves.
Mode of care: Reversal
Find Options for Someone You LoveFor the worried or unsure
I’m concerned about immune-related brain symptoms.
A strategy consultation with our clinical team is the right starting point — to understand whether your symptom pattern warrants a thorough evaluation, not to commit to a diagnosis or treatment.
Mode of care: Active Prevention
Explore Testing & Early EvaluationActive Prevention, Reversal and Optimization are the three modes of care every plan is built in. How the modes differ
The training behind this care
Neuregen connects immune-related concerns with their effects on nervous-system function and everyday activity. Our team reviews the full history and existing care before discussing evidence-labeled options within a shared rehabilitation plan.
Dr. David George: Board certifications and training in functional neurology, integrative psychiatry, and mental health; certified brain injury specialist.
Training most relevant to this area
- Member, International Society for Mast Cell Activation Syndromes
- Member, The Mast Cell Disease Society
These are the founder’s qualifications. We confirm the treating clinician and their role when discussing your plan.
See Dr. George’s full credentialsFrequently asked questions
What is the immune-neurologic connection?
The immune system and nervous system share extensive crosstalk. Pathogenic antibodies can target neural tissue directly. Mast cell activation and innate immune signaling can cross the blood-brain barrier, activate microglia, and impair cerebral blood flow. Post-viral immune dysregulation can sustain neuroinflammation long after the acute illness resolves. Each mechanism produces a different clinical picture — which is why evaluation is the starting point.
Is Neuregen’s use of TPE evidence-based?
It depends on the indication. TPE is an established therapy for classic autoimmune neurologic disease — supported by clinical guidelines and a real evidence base. For mold-related neurologic illness, MCAS, and post-viral presentations, it is labeled investigational or emerging and offered with explicit informed consent. Neuregen is explicit about this distinction; it is central to how the clinic operates.
What is the difference between the Immune flagship and the MCAS hub?
The MCAS hub is diagnosis-specific — for patients who carry an MCAS diagnosis and want to understand how Neuregen addresses the CNS and autonomic picture specifically. The Immune flagship covers the broader category of immune dysregulation affecting the nervous system, including autoimmune-neurologic, mold/Lyme-related, and post-viral presentations alongside MCAS.
Is EBOO a standard treatment for neuroinflammation?
No. EBOO carries investigational evidence at Neuregen — early-stage evidence or a strong mechanistic rationale, offered with explicit informed consent and no outcome guarantee. It is used as an adjunct within a broader rehabilitation plan, not as a standalone neuroinflammatory treatment.
Does Neuregen treat Lyme disease?
Neuregen does not replace infectious disease management of active Lyme disease. Our lane is the neurological and autonomic sequelae that persist after treatment — the domain-level dysfunction that lingers when the infection has been addressed but the nervous system has not recovered.
Start with a Strategy Consultation
If reactions and fatigue are already narrowing where you go or what you can do, it is reasonable to ask for help organizing the picture. The first conversation is about evaluation and options, not choosing a procedure.
8090 N. 85th Way, Suite 100, Scottsdale, AZ 85258 · Mon–Thu, 9:00 AM – 5:30 PM