Start with what life feels like now
What if reactions, fatigue and brain fog overlap?
We help people with unpredictable reactions, fatigue and brain fog by examining immune symptoms alongside other systems so that they can work toward a day that is easier to plan.
How we look at the whole picture
A meal, a smell or an ordinary outing can leave you feeling unwell, and the pattern is difficult to explain.
You may be tracking triggers while also dealing with poor sleep, fatigue or trouble thinking clearly.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
In their own words
We understand your experience of Mast Cell Activation Syndrome
People often describe it in their own words long before anyone gives it a name. If one of these sounds like you, you are in the right place.
“My anxiety and brain fog are much worse after certain foods or environmental exposures.”
“Every allergist says my labs are normal, but something is clearly triggering my nervous system.”
“I’ve been diagnosed with MCAS but nobody addresses the psychiatric and neurological piece.”
“My symptoms span too many systems for any one specialist to manage.”
Illustrative experiences, in the words people commonly use. The portraits are AI-generated and do not show patients.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
Immune symptoms can coexist with changes in energy, autonomic responses and concentration. We look across the seven domains without assuming that one label explains everything.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
We review the timing of symptoms, suspected triggers, prior diagnoses and current care. Testing is chosen to answer specific questions rather than adding a standard panel for everyone.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationNamed Condition Hub
Mast Cell Activation Syndrome
MCAS where brain fog, anxiety, and neurological symptoms dominate
Clinically: Dysregulated mast cell degranulation producing histamine, cytokines, and inflammatory mediators — with CNS and autonomic nervous system as the dominant target organs.
Conceptual artwork for the care discussion. Individual findings and treatment options require clinical evaluation.
What is happening in your nervous system
Mast cell activation releases histamine, cytokines, and other inflammatory mediators that affect multiple systems simultaneously. In Domain 3 (Immune Function & Neuroinflammation), dysregulated mast cells create persistent inflammatory signaling, microglial activation, and — through the blood-brain barrier — neuroinflammation that contributes to brain fog and cognitive dysfunction. In Domain 2 (Autonomic & Nervous System Regulation), histamine and other mediators alter vascular tone, heart rate, and orthostatic tolerance, producing dizziness, palpitations, and autonomic instability that overlap with POTS. Domain 7 (Life, Relationships & Environment) matters directly: environmental triggers — mold exposure, chemical sensitivities, dietary factors — drive mast cell activity and must be identified and addressed alongside clinical treatment.
Domains most involved:
Every plan starts from the same map: the 7 Domains of Recovery.
How it fits your plan
We start with trigger and environment assessment and conventional mast-cell-directed medical management — the most established tools first. Autonomic treatment addresses the Domain 2 picture when sympathetic dysregulation is prominent. Stellate ganglion block may be considered where autonomic involvement is significant. Therapeutic plasma exchange (TPE) specifically for MCAS is offered only where the clinical picture and the informed-consent discussion clearly support its use — it is labeled investigational for this indication. Honest evidence labeling is essential here; Neuregen’s credibility depends on distinguishing what is established from what is exploratory. We default to the simplest, lowest-risk intervention that can move a domain forward — and escalate to more advanced or interventional care only when the evidence and the patient’s course support it.
We review your history, explain the findings, agree on next steps and check how you respond.
Potential Therapies
We use established medicine where it works, and emerging medicine where it makes sense.
These are options to discuss after evaluation, not a predetermined treatment plan. Each label refers to the condition or indication described beside that therapy; evidence can differ for another use. An evidence label does not mean FDA approval.
- Conventional Mast Cell-Directed Medical ManagementEvidence: Established
First-line: antihistamines, mast cell stabilizers, and trigger avoidance.
- Autonomic RehabilitationEvidence: Established
Addressing Domain 2: autonomic instability and orthostatic dysfunction.
- Environmental & Trigger AssessmentEvidence: Established
Domain 7 work: identifying mold, food, and chemical triggers.
- Functional Neurology AssessmentEvidence: Established
Autonomic screen, orthostatic vitals, HRV evaluation.
- Stellate Ganglion Block (SGB)Evidence: Preliminary
Where sympathetic overactivity is a dominant feature of the presentation.
- Therapeutic Plasma Exchange for MCASEvidence: Investigational
For presentations with significant immune dysregulation; offered with explicit informed consent.
- EBOOEvidence: Investigational
As metabolic and neuroinflammatory support; investigational adjunct only.
Where the evidence stands
Evidence varies by therapy and by condition. Each therapy on this page carries its own evidence label for this condition, from established to investigational.
How we grade evidence
Which of these is you?
For the patient
I have MCAS.
You’ve probably seen allergists and immunologists. But if anxiety, brain fog, and autonomic instability are your biggest problems, the CNS picture may not be getting the attention it deserves. Explore a program built around it.
Mode of care: Reversal
Explore Advanced MCAS CareFor a loved one
Someone I love has MCAS.
MCAS can be isolating and hard to explain. We can help you understand the neurological and autonomic dimensions of what your family member is experiencing and what a comprehensive program involves.
Mode of care: Reversal
Find Options for Someone You LoveFor the worried or unsure
I’m not sure if this is MCAS.
A strategy consultation with our clinical team is the right starting point — to understand whether your symptom pattern warrants a thorough evaluation, not to commit to a diagnosis or treatment.
Mode of care: Active Prevention
Explore Testing & Early EvaluationActive Prevention, Reversal and Optimization are the three modes of care every plan is built in. How the modes differ
The training behind this care
Dr. David George: Board certifications and training in functional neurology, integrative psychiatry, and mental health; certified brain injury specialist.
Training most relevant to this area
- Member, International Society for Mast Cell Activation Syndromes
- Member, The Mast Cell Disease Society
These are the founder’s qualifications. We confirm the treating clinician and their role when discussing your plan.
See Dr. George’s full credentialsFrequently asked questions
What makes Neuregen’s MCAS approach different?
Most MCAS practices focus on the physical symptom picture — flushing, GI reactions, anaphylactoid responses. Neuregen’s angle is MCAS where CNS and psychiatric symptoms dominate: brain fog, anxiety, dizziness, and autonomic instability. We evaluate Domains 2 and 3 together rather than treating either in isolation.
How does Neuregen decide whether to use TPE for MCAS?
TPE for MCAS is labeled investigational — not standard of care. It is considered only after conventional mast-cell-directed medical management and autonomic treatment, and only when the clinical picture and informed-consent discussion clearly support its use.
Can MCAS cause brain fog and anxiety?
Mast cells release histamine, cytokines, and other mediators that can cross the blood-brain barrier, activate microglia, and impair cerebral blood flow regulation. These mechanisms are consistent with the brain fog, anxiety, and cognitive symptoms many MCAS patients experience — though evaluation is required to confirm the pattern.
Is mold exposure related to MCAS?
Environmental exposures including mold are a recognized trigger for mast cell activation and are addressed as part of Domain 7 (Life, Relationships & Environment). Neuregen includes trigger and environment assessment in every MCAS evaluation.
Is the MCAS hub different from the Immune flagship?
The MCAS hub is diagnosis-specific — for patients who already carry an MCAS diagnosis and want to understand how we address the CNS and autonomic picture. The Immune flagship covers the broader category of immune dysregulation affecting the nervous system, including autoimmune-neurologic, mold-related, and post-viral presentations.
Start with a Strategy Consultation
A real clinical conversation, not a sales call. We review your history, answer your questions, and discuss with you whether Neuregen is the right fit.
8090 N. 85th Way, Suite 100, Scottsdale, AZ 85258 · Mon–Thu, 9:00 AM – 5:30 PM