Start with what life feels like now
What should you know about TPE for post-viral symptoms?
We help people with symptoms that linger after illness by examining the systems affecting recovery so that they can work toward daily activity at a manageable pace.
How we look at the whole picture
The infection has passed, but you still cannot get through a normal day the way you used to.
A better morning can be followed by a setback after an errand or activity that once felt easy.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
Energy, autonomic responses, cognition, sleep and immune concerns may overlap after an illness. The seven domains give us a way to assess the whole pattern.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
We ask what activity feels like during and afterward, review prior evaluations, and establish a baseline. Your tolerance and response help set the pace of the plan.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationBlood Rehabilitation · Therapeutic Plasma Exchange
TPE for Long COVID & Post-Viral Neuroinflammation
Your plasma carries more than nutrients — it can carry the inflammation, antibodies, and toxins that are quietly working against your brain. TPE clears it and replaces it with a cleaner foundation to rebuild on.
Clinically: An apheresis-based exchange that reduces circulating inflammatory mediators, pathogenic antibodies, and immune complexes — an emerging tool in our practice for post-viral neuroinflammatory presentations, always clearly labeled by evidence level.
Conceptual artwork for the care discussion. Individual findings and treatment options require clinical evaluation.
Post-viral inflammation as a circulating burden
Long COVID and post-viral syndromes can leave persistent circulating immune mediators — autoantibodies, inflammatory cytokines, spike-protein fragments, immune complexes — that continue to affect nervous-system function long after the acute infection has resolved. Domains 2, 3, and 4 are typically all involved: autonomic dysregulation, neuroinflammation, and metabolic disruption run together.
The rationale for TPE in this context is to reduce that circulating burden as one step in a sequenced recovery plan. Blood rehabilitation is not the whole plan — it is the soil-preparation step before sustained neurorehabilitation, autonomic work, and metabolic support become more effective.
Researchers are actively investigating plasma-based approaches for complex post-infectious conditions. Neuregen's clinical designation of emerging reflects that: promising evidence, not yet standard of care. Neuregen says so plainly and labels it at every consultation.
Domains most involved:
Every plan starts from the same map: the 7 Domains of Recovery.
How it fits your plan
TPE for Long COVID neuroinflammation sits in the Treat phase — after autonomic and immune baseline testing has established that circulating inflammatory burden is a meaningful target in the patient's presentation. It is combined with autonomic rehabilitation (Domain 2) and metabolic support (Domain 4) rather than offered as a stand-alone infusion.
Blood therapies only make sense in relation to a specific clinical question. We review the indication, evidence and risks for TPE or EBOO separately, then consider whether either has a role alongside rehabilitation and your existing medical care.
We review your history, explain the findings, agree on next steps and check how you respond.
Potential Therapies
We use established medicine where it works, and emerging medicine where it makes sense.
These are options to discuss after evaluation, not a predetermined treatment plan. Each label refers to the condition or indication described beside that therapy; evidence can differ for another use. An evidence label does not mean FDA approval.
- Therapeutic Plasma Exchange (TPE)Evidence: Emerging
Emerging evidence for post-viral neuroinflammatory presentations. Promising; not yet standard of care for this specific indication.
- EBOO / EBO2 (metabolic and brain-energy support)Evidence: Investigational
Investigational adjunct for metabolic and brain-energy support in post-viral presentations. Offered as part of a broader plan, not as a stand-alone procedure.
Where the evidence stands
Researchers are actively investigating plasma-based approaches for complex post-infectious conditions, including Long COVID. Neuregen designates TPE for this indication as emerging — promising clinical evidence, not yet standard of care. We discuss the current evidence base and realistic expectations at every medical consultation.
Sources and what they support
- ASFA 2023 guidelines for therapeutic apheresis
Apheresis recommendations are indication-specific. An established use for one disease does not establish TPE for Alzheimer’s, Long COVID, MCAS or environmental illness.
- CDC clinical overview of Long COVID
Background on Long COVID and its effects across body systems. This overview does not establish the effectiveness of TPE, EBOO or SGB for Long COVID.
How we grade evidence
Pricing
| Service | Price |
|---|---|
| Therapeutic plasma exchange, single procedure | Confirmed in writing at your Strategy Consultation |
| TPE seriesSeries length depends on the indication and your response | Confirmed in writing at your Strategy Consultation |
Neuregen is an out-of-network specialty clinic. Most therapies listed here are not covered by insurance; we provide itemized documentation you can submit to your insurer, and we tell you before any therapy which parts, if any, are typically reimbursed.
Financing options are reviewed at your Strategy Consultation before any plan is finalized.
The training behind this care
Neuregen brings the blood-therapy discussion into the same plan as neurologic, autonomic and functional care. We ask what a proposed intervention would change in daily life and how that change would be assessed.
Dr. David George: Board certifications and training in functional neurology, integrative psychiatry, and mental health; certified brain injury specialist.
Training most relevant to this area
- Member, American Society for Apheresis (ASFA)
- GCP Certified (NIDA)
These are the founder’s qualifications. We confirm the treating clinician and their role when discussing your plan.
See Dr. George’s full credentialsFrequently asked questions
Is TPE proven for Long COVID?
No. TPE for Long COVID and post-viral neuroinflammatory presentations is classified as emerging at Neuregen — promising evidence, actively investigated, but not yet a standard of care for this specific indication. Neuregen says so plainly at every consultation. Promising does not mean proven.
What makes Long COVID a candidate for a blood-based approach?
Post-viral syndromes can leave persistent circulating autoantibodies, inflammatory cytokines, and immune complexes that continue to affect nervous-system function. TPE targets those circulating factors directly. The mechanistic rationale is grounded in TPE's established role in removing pathogenic plasma constituents — applied here in an emerging, not established, context.
Would EBOO also be part of a Long COVID plan?
Possibly. EBOO is positioned as metabolic and brain-energy support — an investigational adjunct that addresses Domain 4 alongside the immune work of TPE. Whether EBOO belongs in a given Long COVID plan is determined by our clinical team after a full medical review.
How does this fit into a broader Long COVID rehabilitation plan?
At Neuregen, blood rehabilitation is step one in a sequenced plan for these patients — followed by autonomic rehabilitation (Domain 2), metabolic support (Domain 4), neurorehabilitation (Domain 1), and psychiatric integration (Domain 6) where indicated. The blood work is intended to improve the internal biologic environment so that subsequent rehabilitation becomes more effective.
Start with a Strategy Consultation
Ongoing fatigue or difficulty thinking may already be limiting your work and family life. An evaluation can help organize what is known, what remains uncertain and whether further investigation is useful before considering blood therapy.
8090 N. 85th Way, Suite 100, Scottsdale, AZ 85258 · Mon–Thu, 9:00 AM – 5:30 PM