Start with what life feels like now
What is known and uncertain about EBOO?
We help people with fatigue, dizziness or brain fog by examining the systems involved together so that they can work toward the activities they miss.
How we look at the whole picture
You used to run for miles. Now a short walk, a workday or a trip to the store can leave you exhausted.
You have seen different specialists, but you still need someone to explain how the pieces fit together.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
A racing heart, poor sleep, neck pain and trouble concentrating can affect the same day. The seven-domain approach asks how those problems interact, rather than assuming each belongs in a separate appointment.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
Bring the story of what changed: what you could do before, what you can do now, and what happens afterward. We review that alongside your prior evaluations and choose assessments that answer the remaining questions.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationBlood Rehabilitation
EBOO / EBO2
Extracorporeal Blood Oxygenation and Ozonation
Your brain runs on oxygen and clean fuel. EBOO filters, oxygenates, and re-energizes your blood before it goes back to work for your brain.
Clinically: An extracorporeal blood oxygenation and ozonation protocol positioned as metabolic and brain-energy support — offered as an investigational adjunct within a broader rehabilitation plan, not as a standalone longevity procedure.
Neuroinflammatory Support
Evidence: InvestigationalEarly-stage evidence; offered as an adjunct within a broader rehabilitation plan, with explicit informed consent and no outcome guarantee.EBOO is positioned as an investigational adjunct within Neuregen’s broader rehabilitation plan. Proposed mechanisms include support for oxygen utilization, redox signaling, cellular energy, and immunomodulatory effects. Direct evidence for neuroinflammatory applications remains limited and evolving.
How EBOO works
Blood is drawn through a vascular access line and passed through an extracorporeal circuit.
The blood is filtered, then oxygenated and treated with medical-grade ozone.
The treated blood is returned to the patient.
Proposed effects include support for oxygen utilization, redox signaling, and cellular energy; ozone-based therapies have also been studied for immunomodulatory effects, though evidence varies by condition and protocol.
Improved vascular function and reduced physiologic stress have been proposed as downstream effects, but direct evidence remains limited. Any effects on neural networks are considered indirect — by improving the physiologic milieu rather than directly altering neural circuitry.
Who it may help
EBOO at Neuregen is considered for selected patients within a broader rehabilitation plan — particularly in the context of neuroinflammatory presentations, Long COVID, post-viral syndromes, and complex immune dysregulation. It is not offered as a general wellness or longevity procedure outside a clinical framework.
At a strategy consultation, we discuss whether EBOO has a role in your care. All treatment plans are set by our clinical team after a thorough medical review.
What to expect
EBOO is performed in a clinical setting via vascular access and an extracorporeal ozonation circuit. The plan length and sequencing within the broader rehabilitation program are reviewed by our clinical team at the strategy consultation after a full medical review. EBOO is typically positioned as one component in a recovery sequence that includes neurorehabilitation and metabolic support.
Where EBOO fits in the 7 Domains
EBOO maps to Domain 4 (Metabolic / Brain Energy) through proposed support for oxygen utilization, redox signaling, and cellular energy, and to Domain 3 (Immune Regulation) through immunomodulatory mechanisms. Domain 2 (Autonomic) and Domain 1 (Neural Networks) effects are considered indirect and evidence remains limited.
Important to know
Neuregen is an out-of-network specialty clinic. Patients are responsible for fees at the time of service.
A Strategy Consultation determines candidacy before any treatment is recommended.
All treatment plans are set by our clinical team after a thorough medical review.
How it fits your plan
Your care · Treat
Blood therapies only make sense in relation to a specific clinical question. We review the indication, evidence and risks for TPE or EBOO separately, then consider whether either has a role alongside rehabilitation and your existing medical care.
We review your history, explain the findings, agree on next steps and check how you respond.
Apheresis and environmental-medicine credentials behind this program
Neuregen brings the blood-therapy discussion into the same plan as neurologic, autonomic and functional care. We ask what a proposed intervention would change in daily life and how that change would be assessed.
Dr. David George: Board certifications and training in functional neurology, integrative psychiatry, and mental health; certified brain injury specialist.
Training most relevant to this area
- Member, American Society for Apheresis (ASFA)
- GCP Certified (NIDA)
These are the founder’s qualifications. We confirm the treating clinician and their role when discussing your plan.
See Dr. George’s full credentialsEBOO / EBO2 pricing
| Service | Price |
|---|---|
| EBOO / EBO2, single session | Confirmed in writing at your Strategy Consultation |
| EBOO series | Confirmed in writing at your Strategy Consultation |
Neuregen is an out-of-network specialty clinic. Most therapies listed here are not covered by insurance; we provide itemized documentation you can submit to your insurer, and we tell you before any therapy which parts, if any, are typically reimbursed.
Financing options are reviewed at your Strategy Consultation before any plan is finalized.
Frequently asked questions
What is EBOO / EBO2?
EBOO (Extracorporeal Blood Oxygenation and Ozonation) is a procedure that filters, oxygenates, and treats blood with medical-grade ozone outside the body before returning it. Proposed mechanisms include support for oxygen utilization, redox signaling, and cellular energy, as well as immunomodulatory effects. Evidence for these mechanisms is evolving, and EBOO is classified as investigational at Neuregen for neuroinflammatory support.
Why does Neuregen classify EBOO as investigational?
Because the evidence base for EBOO in neuroinflammatory conditions is early-stage. Neuregen’s evidence-labeling system exists precisely for this: promising does not mean proven. EBOO is offered as an adjunct within a broader rehabilitation plan, with explicit informed consent and no outcome guarantee.
How is EBOO different from standard IV ozone therapy?
EBOO involves extracorporeal processing — blood is drawn, passed through a filtration and ozonation circuit outside the body, then returned. Standard ozone therapies do not involve this extracorporeal circuit. The larger volume processed and the filtration step differentiate EBOO from simpler ozone protocols.
Can EBOO be combined with TPE?
The sequencing of any two therapies — including TPE and EBOO — is determined by our clinical team after a full medical review. Neuregen does not prescribe standard bundles; the plan is individualized.
Is EBOO covered by insurance?
Neuregen is an out-of-network specialty clinic. Patients are responsible for fees at the time of service. Pricing is provided in writing at the strategy consultation.
Every plan starts from the same map: the 7 Domains of Recovery.
Start with a Strategy Consultation
Ongoing fatigue or difficulty thinking may already be limiting your work and family life. An evaluation can help organize what is known, what remains uncertain and whether further investigation is useful before considering blood therapy.
8090 N. 85th Way, Suite 100, Scottsdale, AZ 85258 · Mon–Thu, 9:00 AM – 5:30 PM