Start with what life feels like now
When might ketamine belong in psychiatric care?
We help people with depression or anxiety that disrupts daily life by considering mental and physical symptoms together so that they can work toward participating in relationships and routines again.
How we look at the whole picture
You have tried to explain how difficult ordinary days have become, and you may have already tried more than one approach.
Sleep, concentration, energy and physical symptoms may be adding to what you are carrying.
You do not need to know which treatment to ask for. Start with what has changed and what you want to be able to do again.
The 7 Domains of Recovery™
Your symptoms may belong in the same conversation.
Psychological health is one of seven domains, not an isolated part of you. We consider how mood, cognition, sleep, physical symptoms and circumstances affect each other.
Neuregen's proprietary 7 Domains of Recovery framework organizes that conversation around seven connected parts of your life and health. We consider all seven, then focus the evaluation on the questions your history raises.
Explore our clinical framework- 1Brain function & neural networks
What has changed in your memory, concentration, balance or sensory tolerance?
- 2Autonomic & nervous system regulation
What happens when you stand, move, rest or encounter stress?
- 3Immune function & neuroinflammation
What immune history, reactions or symptoms need a closer look?
- 4Brain energy & metabolic health
What affects your energy through the day and after activity?
- 5Structure, stability & body-to-brain signals
How do pain, posture, movement and stability affect what you can do?
- 6Psychological flexibility & behavioral recovery
How are mood, stress and patterns of coping affecting your day?
- 7Life, relationships & environment
What demands, relationships and support shape your recovery?
A plan starts with the things you want to do again.
We review your history, current symptoms, previous responses and priorities. You and the clinical team discuss the options, tradeoffs and how progress will be assessed.
01
Tell us what you want your life to look like
We start with what has changed, what you have tried, and the activities you most want to return to.
02
Answer the questions the history leaves open
We review prior reports and select relevant assessments. You should understand what each assessment is meant to clarify.
03
Agree on the priorities and the first steps
We discuss the findings, possible approaches, costs and practical constraints. The plan sets an order that fits your situation.
04
Check what changes and adjust together
We compare your response with the starting point, including daily function. If something is not helping, we discuss what needs to change.
Only then do we discuss which therapies, if any, belong in your plan. The choice depends on the findings, the evidence, your preferences and how you respond.
Talk through your situationIntegrative Psychiatry
Ketamine Therapy
When a nervous system has been stuck in the same protective patterns for years, ketamine can open a window where real change becomes possible — and we make sure that window is used well.
Clinically: Sub-anesthetic ketamine, delivered within a psychiatrically integrated program — paired, where appropriate, with autonomic and structural rehabilitation rather than offered as an isolated infusion.
Conceptual artwork for the care discussion. Individual findings and treatment options require clinical evaluation.
Read the full transcript
When your mind keeps returning to the same stuck place, there's a way to open a window for real change. Ketamine works differently to most psychiatric medications. It can open a window where the brain's stuck patterns can become flexible again. Used well, that therapeutic window can be where the real therapeutic work happens. We don't just hand you a ketamine session and send you home. We most often pair ketamine with real psychiatric care. You're comfortable and monitored the whole time. Most sessions run about an hour, and we're right there with you before, during and after. If you're wanting to try something different and you think that this window might be right for you, we'd love to talk.
How ketamine works in the nervous system
Ketamine acts on NMDA receptors and triggers downstream release of BDNF (Brain-Derived Neurotrophic Factor) and activation of the mTOR pathway, which together stimulate synaptic growth — neuroplasticity — more rapidly than most conventional antidepressants. It also disrupts hyperactivity in the default mode network, a pattern associated with depressive rumination.
The questions that matter are why ketamine, why now, and what else is happening alongside it. Ketamine is chosen when a protective pattern has outlasted standard treatment and the nervous system needs a reset it cannot produce on its own. The timing is set by the baseline assessment, after any medical or autonomic drivers that would blunt the response are identified. And it is never the whole plan: psychiatric care, autonomic work, and, where trauma keeps the body in a threat state, stellate ganglion block run alongside it so the neuroplastic window is filled with something durable.
This creates a period of heightened neuroplastic potential in the days following infusion. How that window is used determines the durability of the effect. Neuregen pairs the infusion with therapeutic context — and, where appropriate, with the autonomic and structural rehabilitation work in the broader program — so the neuroplastic window is not wasted.
Domains most involved:
Every plan starts from the same map: the 7 Domains of Recovery.
How it fits your plan
Ketamine is considered after a psychiatric evaluation and discussion of previous care. If it is appropriate, we explain the evidence, risks, alternatives and how support and follow-up will work.
Mood, sleep, concentration and physical symptoms can affect the same parts of your day. We consider them together before discussing a specific psychiatric approach, so psychotherapy or medication decisions fit the wider care plan.
We review your history, explain the findings, agree on next steps and check how you respond.
Potential Therapies
We use established medicine where it works, and emerging medicine where it makes sense.
These are options to discuss after evaluation, not a predetermined treatment plan. Each label refers to the condition or indication described beside that therapy; evidence can differ for another use. An evidence label does not mean FDA approval.
- Sub-anesthetic IV ketamineEvidence: Established
ESTABLISHED for treatment-resistant depression and major depressive disorder. Evidence base includes multiple randomized controlled trials and professional society recognition.
- KAP (ketamine-assisted psychotherapy) componentEvidence: Emerging
The psychotherapy integration layer — available as a separate tier for patients who want structured therapeutic work paired with the dosing session.
- PHQ-9, GAD-7, PCL-5 outcome tracking
Validated tools to establish baseline and measure response at defined intervals.
Where the evidence stands
Ketamine is supported by a substantial evidence base for treatment-resistant depression and major depressive disorder, including professional society recognition and FDA approval of esketamine (Spravato) for TRD. The evidence for ketamine in PTSD and AUD/craving is labeled separately on those indication pages.
How we grade evidence
Pricing
| Service | Price |
|---|---|
| Ketamine therapy, single session | Confirmed in writing at your Strategy Consultation |
| Ketamine therapy, 6-session series | Confirmed in writing at your Strategy Consultation |
| Ketamine-assisted psychotherapy (KAP) sessionIncludes the psychotherapy component; priced separately from infusion-only sessions | Confirmed in writing at your Strategy Consultation |
| Ketamine maintenance sessionBooster sessions after a completed series, scheduled by response | Confirmed in writing at your Strategy Consultation |
Ketamine therapy is typically not covered by insurance. Spravato (esketamine) is sometimes covered when prescribed under its approved indications; we will tell you which applies to you before you commit.
Financing options are reviewed at your Strategy Consultation before any plan is finalized.
The training behind this care
Neuregen combines integrative psychiatric care with nervous-system rehabilitation. Our team can discuss psychological and physical concerns in the same clinical context, while explaining the qualifications and role of each treating clinician.
Dr. David George: Board certifications and training in functional neurology, integrative psychiatry, and mental health; certified brain injury specialist.
Training most relevant to this area
- Certified Clinical Trauma Professional (CCTP)
- PMHNP-BC
- Active Psychotherapist
- Certified Hypnotherapist
- CBT-I (Cognitive Behavioral Therapy for Insomnia) trained
These are the founder’s qualifications. We confirm the treating clinician and their role when discussing your plan.
See Dr. George’s full credentialsRelated pages
modality
Frequently asked questions
What is integrative ketamine therapy?
Ketamine is administered at sub-dissociative doses alongside counseling support. As an NMDA receptor antagonist, it triggers a rapid release of glutamate that stimulates the growth of new connections between brain cells (synaptogenesis). Neuregen's integrative approach pairs the infusion with therapeutic context so the neuroplastic window is used purposefully.
Who may be a candidate for ketamine therapy at Neuregen?
We consider ketamine for patients with major depressive disorder (MDD), treatment-resistant depression (TRD), complex neuropsychiatric presentations, and severe PTSD. A Strategy Consultation determines whether ketamine is appropriate for your situation.
What happens during and after an infusion?
Infusions are given at sub-dissociative doses with counseling support present. New synaptic growth is most active in the days following each infusion. The number of sessions and the pacing of the course are set by our clinical team after a full medical review — not in advance.
Why is this called "integrative" ketamine rather than standard ketamine therapy?
The integration refers to the counseling and contextual support that runs alongside the infusion, not just the infusion itself. The goal is to use the period of heightened neuroplasticity that ketamine creates to support lasting change rather than simply repeating an intervention.
How does ketamine affect the brain differently from antidepressants?
Traditional antidepressants generally modulate serotonin or norepinephrine over weeks. Ketamine acts on NMDA receptors and triggers BDNF (Brain-Derived Neurotrophic Factor) expression and mTOR pathway activity, which together can stimulate synaptic growth more rapidly. It also disrupts default mode network hyperactivity that is associated with depressive rumination.
Is Neuregen an in-network provider for ketamine therapy?
Neuregen is an out-of-network specialty clinic. Patients are responsible for fees at the time of service. Ketamine therapy is typically not covered by insurance; Spravato (esketamine) may have coverage under its approved indications.
Start with a Strategy Consultation
When distress or poor sleep keeps affecting relationships and everyday responsibilities, putting off a conversation leaves those concerns unresolved. You can ask about next steps without committing to medication or a procedure.
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